Table 1.
Demographic characteristics.
| European Ancestry YCAAD | Controls n=39 | Non-Severe n=137 | Severe n=37 | P value |
|---|---|---|---|---|
| Age (years) | 45 [31-57] | 46 [36-56] | 59 [50-68] | <0.01 |
| Female sex | 27(69%) | 98 (72%) | 23 (62%) | 0.52 |
| Age of Onset | - | 22 [5-40] | 21 [4-45] | 0.46 |
| BMI (Kg/m2) | 25.5 [23.5-27.8] | 26.3 [22.7-31.2] | 29.3 [25.0-31.5] | 0.08 |
| FEV1 Pre-BD PP | 99 [91-105] | 89 [79-98] | 53 [39-59] | <0.01 |
| FEV1 Post-BD PP | 104 [96-110] | 95 [84-106] | 60 [45-70] | <0.01 |
| FeNO (ppb) | 22 [13-29] | 26 [19-60] | 40 [24-54] | 0.02 |
| Total IgE (IU/mL) | 20 [11-72] | 95 [29-225] | 129 [26-289] | 0.61 |
| Serum YKL-40 (ng/mL)* | 43 [31-67] | 65 [37-105] | 83 [37-110] | 0.01 |
| European Ancestry SARP | Controls n=122 | Non-Severe n=234 | Severe n=328 | P value |
| Age (years) | 27 [23-40] | 31 [22-41] | 41 [31-51] | <0.01 |
| Female sex | 68 (66%) | 168 (72%) | 190 (58%) | 0.29 |
| Age of Onset | - | 10 [4-22] | 12 [3-30] | 0.06 |
| BMI (Kg/m2) | 24.4 [21.7-28.4] | 25.1 [22.1-29.3] | 28.7 [24.4-34.0] | <0.01 |
| FEV1 Pre-BD PP | 98 [93-105] | 89 [82-99] | 60 [43-75] | <0.01 |
| FEV1 Post-BD PP | 105 [97-110] | 97 [89-107] | 71 [36-86] | <0.01 |
| FeNO (ppb) | 14 [11-20] | 26 [17-52] | 29 [17-52] | 0.03 |
| Total IgE (IU/mL) | 35 [15-83] | 117 [49-232] | 115 [29-305] | 0.05 |
| Serum YKL-40 (ng/mL)* | 43 [33-53] | 44 [32-60] | 60 [41-101] | <0.01 |
| African Ancestry SARP and YCAAD | Controls n=22 | Non-Severe n=132 | Severe n=127 | P value |
| Age (years) | 35 [29-40] | 29 [22-40] | 36 [22-45] | 0.79 |
| Female sex | 16 (73%) | 88 (66%) | 82 (65%) | 0.48 |
| Age of Onset | - | 8 [2-18] | 4 [1-17] | 0.66 |
| BMI (Kg/m2) | 28.7 [25.8-34.7] | 29.0 [24.7 -36.6] | 32.3 [23.5-37.5] | 0.50 |
| FEV1 Pre-BD PP | 103 [96-110] | 87 [80-96] | 62 [52-77] | <0.01 |
| FEV1 Post-BD PP | 108 [101-117] | 98 [89-107] | 80 [66-93] | <0.01 |
| FeNO (ppb) | 18 [16-28] | 28 [15-55] | 30 [18-44] | 0.63 |
| Total IgE (IU/mL) | 66 [39-162] | 150 [47-376] | 201 [69-569] | 0.02 |
| Serum YKL-40 (ng/mL)* | 41 [29-47] | 39 [23-65] | 60 [32-79] | 0.33 |
Values expressed as n and (percentage) or median and [interquartile range].
*
Number (Percentage) with available measurements: European Ancestry YCAAD=213 (100%); European Ancestry SARP=143 (22%); African Ancestry SARP and YCAAD=92 (33%)
Definition of Abbreviations: YCAAD = Yale Center for Asthma and Airways Disease; SARP = Severe Asthma Research Program; BMI = Body Mass Index; FEV1 = Forced Expiratory Volume in One Second; Pre-BD = Pre-bronchodilator; PP= Percent of predicted; Post-BD=Post-bronchodilator; FeNO = Fractional exhaled nitric oxide; ppb = parts per billion; IgE = Immunoglobulin E.