Table 3. Haplotype analysis in individuals of European ancestry in YCAAD and SARP.
Haplotype | Frequency | Phenotype | Effect size and direction | P Value | rs2275353 | rs12141494 | rs1538372 | rs495928 | rs1399805 |
---|---|---|---|---|---|---|---|---|---|
A | 18% | FEV1 PP Post-BD | 4 | <0.01 | G | G | A | G | G |
A | 20% | Serum YKL-40 | -24 | <0.01 | G | G | A | G | G |
B | 14% | FEV1 PP Post-BD | 6 | <0.01 | A | G | G | C | A |
B | 15% | Serum YKL-40 | -0.6 | 0.93 | A | G | G | C | A |
C | 12% | FEV1 PP Post-BD | 2 | 0.19 | G | G | A | C | G |
C | 13% | Serum YKL-40 | -0.1 | 0.99 | G | G | A | C | G |
Base | 51% | G | A | G | C | G |