Table 1.
Percentage of G-MDSCs and macrophages that were positive for OPSS- or control-liposomes in different tissues. Macrophages were not detected in high enough numbers to analyze in the blood samples. Data are expressed as mean ± SE of triplicate samples. G-MDSC were chosen based on the positive expression of Ly6C, Ly6G and CD11b, while selected macrophages were positive for CD11b and F4/80.
| G-MDSCs | Macrophages | |||
|---|---|---|---|---|
| OPSS | Control | OPSS | Control | |
| Blood | 22.0 ± 4.9 | 0.3 ± 0.1 | NA | NA |
| Tumor | 10.8 ± 3.0 | 1.9 ± 1 | 3.7 ± 1.3 | 2.4 ± 0.6 |
| Spleen | 21.6 ± 3.0 | 0.9 ± 0.2 | 33.9 ± 2.9 | 27.5 ± 2.0 |
| Liver | 35.3 ± 6.2 | 2.9 ± 0.6 | 79.2 ± 3.8 | 70.4 ± 1.4 |
| Lungs | 25.5 ± 1.6 | 0.7 ± 0.3 | 56.0 ± 15.9 | 42.4 ± 12.9 |