TABLE II.
DMRs associated with asthma at an SLK-Sidak P value of less than .05
| Chromosome | Start | End | No. of probes |
Asthma SLK P value |
Asthma SLK-Sidak P value |
Gene | Location | CpG island distance |
Methylation difference (asthma- control [%]) |
FEV1 P value |
IgE P value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| chr1 | 1091164 | 1091325 | 4 | 5.59E-07 | .00168 | CS444397 | 1075 | 717 | −0.012 | .003504 | |
| chr1 | 2220460 | 2220783 | 4 | 4.52E-07 | .00068 | SKI | Intron | 0 | −0.015 | ||
| chr1 | 6263726 | 6263914 | 4 | 3.79E-08 | 9.79E-05 | ACOT7 | Exon;intron;nc_ exon;nc_intron |
0 | −0.011 | ||
| chr1 | 6277594 | 6277647 | 2 | 1.41E-07 | .0013 | ACOT7 | Exon;intron;nc_ exon;nc_intron |
0 | −0.02 | .03596 | |
| chr1 | 15264894 | 15265020 | 2 | 4.38E-10 | 1.69E-06 | LOC391005 | Intron;utr3 | 0 | −0.029 | .03778 | |
| chr1 | 18883602 | 18883759 | 2 | 3.83E-06 | .01177 | PAX7 | Intron | 0 | −0.017 | ||
| chr1 | 21750110 | 21750368 | 5 | 3.59E-06 | .00673 | ALPL | utr5_intron | 23,263 | −0.01 | ||
| chr1 | 21773573 | 21773847 | 3 | 3.79E-06 | .00668 | ALPL | Intron | 0 | −0.03 | ||
| chr1 | 25113451 | 25113525 | 3 | 1.63E-07 | .00107 | RUNX3 | Intron | 0 | −0.018 | ||
| chr1 | 27555725 | 27556088 | 5 | 1.96E-07 | .00026 | MAP3K6 | Exon;intron | 0 | −0.018 | ||
| chr1 | 45046081 | 45046267 | 3 | 1.74E-05 | .04438 | TCTEX1D4 | −537 | 1,268 | 0.006 | .01963 | |
| chr1 | 110108029 | 110108165 | 3 | 5.01E-07 | .00179 | EPS8L3 | utr5 | 23,218 | −0.01 | .01368 | |
| chr1 | 152566740 | 152566865 | 2 | 5.46E-06 | .021 | ATP8B2 | utr5_intron | 807 | 0.012 | .03256 | |
| chr1 | 213807046 | 213807324 | 3 | 2.66E-05 | .0453 | KCTD3 | 34 | 0 | 0.002 | ||
| chr1 | 227230174 | 227230200 | 2 | 2.00E-06 | .03665 | AX748369 | −110597 | 119,496 | 0.01 | ||
| chr2 | 8339686 | 8339783 | 3 | 9.66E-08 | .00048 | LINC00299 | nc_intron | 77,665 | −0.019 | .03115 | |
| chr2 | 8340572 | 8340606 | 2 | 1.02E-06 | .01438 | LINC00299 | nc_intron | 76,842 | −0.017 | ||
| chr2 | 27652710 | 27652915 | 3 | 7.47E-06 | .01754 | C2orf16 | utr5 | 6,296 | −0.013 | ||
| chr2 | 66518038 | 66518302 | 3 | 4.82E-07 | .00089 | MEIS1 | Intron | 1 | 0.009 | ||
| chr2 | 232101307 | 232101500 | 3 | 1.15E-08 | 2.90E-05 | NMUR1 | Exon | 0 | −0.018 | .0002612 | |
| chr2 | 242516227 | 242516284 | 2 | 5.56E-07 | .00472 | AK097934 | 45223 | 707 | −0.025 | ||
| chr3 | 11626535 | 11626881 | 3 | 1.25E-07 | .00018 | VGLL4 | Intron | 0 | −0.012 | ||
| chr3 | 52787406 | 52787560 | 4 | 5.39E-06 | .01686 | ITIH1 | Exon;nc_exon | 7,238 | −0.013 | ||
| chr3 | 115495348 | 115495602 | 4 | 1.67E-05 | .03144 | TIGIT | Exon;utr5 | 16,590 | −0.01 | ||
| chr4 | 1233848 | 1234086 | 7 | 5.29E-07 | .00108 | AK125775 | nc_exon | 0 | −0.018 | ||
| chr5 | 125723585 | 125723747 | 3 | 3.32E-10 | 9.96E-07 | GRAMD3 | 63253 | 63,229 | −0.012 | .03647 | |
| chr5 | 132021512 | 132021960 | 6 | 5.34E-08 | 5.79E-05 | IL13 | Exon;intron;utr5 | 1,309 | −0.008 | ||
| chr6 | 458210 | 458297 | 2 | 4.91E-06 | .027 | EXOC2 | Intron | 2,395 | −0.014 | ||
| chr6 | 26334181 | 26334235 | 2 | 1.41E-07 | .00126 | HIST1H3F | utr3 | 0 | −0.009 | ||
| chr6 | 29019737 | 29020145 | 10 | 8.39E-07 | .001 | TRIM27 | −19990 | 0 | 0.017 | ||
| chr6 | 31954747 | 31955007 | 10 | 6.90E-06 | .01281 | SLC44A4 | utr5 | 0 | −0.015 | ||
| chr6 | 31975676 | 31976004 | 20 | 2.89E-08 | 4.28E-05 | C2;ZBTB12 | Exon;utr3;utr5_ intron |
0 | −0.015 | .01655 | |
| chr6 | 109881430 | 109881854 | 3 | 1.42E-08 | 1.62E-05 | MICAL1 | Exon;intron | 942 | −0.008 | ||
| chr7 | 888576 | 888761 | 3 | 3.47E-08 | 9.11E-05 | GET4;SUN1 | Intron;nc_intron | 0 | −0.005 | ||
| chr7 | 2056125 | 2056406 | 3 | 7.89E-07 | .00136 |
MAD1; MAD1L1 |
Intron | 0 | −0.016 | .01102 | |
| chr7 | 2695301 | 2695438 | 3 | 8.55E-06 | .02983 | AMZ1 | utr5_intron | 0 | −0.013 | ||
| chr7 | 38323253 | 38323572 | 4 | 2.71E-06 | .00412 | TCRg;TRGV9 | Exon;intron;nc_ exon |
5,468 | −0.021 | ||
| chr7 | 73283658 | 73283902 | 4 | 9.19E-08 | .00018 | RFC2 | utr3 | 0 | −0.017 | ||
| chr7 | 74890962 | 74891132 | 3 | 1.05E-05 | .0296 | POM121C | Intron | 0 | −0.01 | .00866 | |
| chr8 | 125532162 | 125532491 | 6 | 1.73E-06 | .00255 | TRMT12 | Exon;utr5 | 0 | 0.016 | 9.29E-08 | |
| chr8 | 127638762 | 127638859 | 4 | 8.24E-07 | .00412 | FAM84B | Exon;utr5 | 0 | −0.008 | .0131 | |
| chr10 | 848816 | 848923 | 3 | 8.24E-06 | .0367 | LARP5 | Exon;utr3 | 1,721 | −0.012 | .03864 | |
| chr10 | 3813757 | 3814016 | 5 | 8.39E-09 | 1.57E-05 | KLF6 | Exon;intron | 0 | −0.021 | ||
| chr10 | 3814386 | 3814687 | 4 | 3.08E-08 | 4.96E-05 | KLF6 | Exon;intron | 88 | −0.024 | ||
| chr10 | 72030353 | 72030454 | 3 | 1.27E-07 | .00061 | PRF1 | Exon | 0 | −0.015 | .01763 | |
| chr10 | 101814909 | 101815175 | 5 | 3.92E-06 | .00713 | CPN1 | Exon;intron | 0 | −0.016 | ||
| chr10 | 126320834 | 126321170 | 4 | 2.03E-07 | .00029 | FAM53B | Intron | 246 | −0.016 | .0125 | |
| chr10 | 134072207 | 134072497 | 4 | 2.63E-06 | .0044 | PWWP2B | Intron;utr3_intron | 0 | −0.009 | .00745 | |
| chr11 | 34416873 | 34417133 | 7 | 7.88E-07 | .00147 | CAT | utr5 | 0 | −0.018 | .01748 | |
| chr11 | 36377805 | 36377877 | 2 | 7.07E-07 | .00475 | FLJ14213 | Intron;utr5_intron | 21,831 | −0.01 | .006936 | |
| chr11 | 62378748 | 62378810 | 3 | 1.62E-06 | .01262 | SNHG1 | nc_intron | 696 | 0.007 | ||
| chr11 | 64289922 | 64290199 | 3 | 3.71E-06 | .00647 | SF1 | Exon;intron | 0 | −0.009 | .02808 | |
| chr11 | 129485687 | 129485739 | 3 | 2.10E-06 | .01937 | APLP2 | Exon;utr5_intron | 13,029 | −0.007 | .0003045 | |
| chr12 | 122162107 | 122162366 | 2 | 3.43E-08 | 6.43E-05 | PITPNM2 | utr5_intron | 38,347 | −0.021 | ||
| chr12 | 130134393 | 130134600 | 4 | 1.33E-05 | .03062 | GPR133 | Intron;utr5_intron | 0 | −0.006 | ||
| chr13 | 113220890 | 113221025 | 3 | 1.19E-05 | .04192 | TMCO3 | Intron | 0 | −0.015 | .0001811 | |
| chr13 | 113825056 | 113825282 | 3 | 1.34E-05 | .02828 | RASA3 | Intron;utr5_intron | 0 | −0.007 | ||
| chr14 | 98857115 | 98857373 | 3 | 3.11E-06 | .00583 | BCL11B | −49540 | 0 | −0.015 | ||
| chr14 | 104255101 | 104255221 | 3 | 2.80E-06 | .01125 | INF2 | Intron;nc_intron; utr3_intron |
0 | −0.013 | ||
| chr15 | 89170960 | 89171237 | 2 | 2.72E-05 | .0465 | BLM | − 11270 | 0 | −0.013 | .0374 | |
| chr16 | 84108978 | 84109249 | 3 | 1.59E-06 | .00285 | KIAA0182 | 93281 | 0 | −0.01 | ||
| chr16 | 84233792 | 84234027 | 4 | 1.86E-05 | .03767 | KIAA0182 | Intron;utr5_intron | 0 | −0.011 | ||
| chr16 | 85272036 | 85272335 | 4 | 1.63E-06 | .00264 | BC041439 | 39457 | 0 | −0.012 | ||
| chr16 | 87075079 | 87075362 | 3 | 1.39E-05 | .02358 | ZFPM1 | Intron | 1,919 | −0.003 | ||
| chr16 | 87085565 | 87085738 | 3 | 1.59E-06 | .00444 | ZFPM1 | Intron | 0 | −0.018 | ||
| chr17 | 37379133 | 37379307 | 3 | 5.59E-08 | .00016 | CNP | Exon | 0 | −0.015 | .00594 | |
| chr17 | 38531660 | 38531955 | 12 | 1.59E-08 | 2.62E-05 | NBR2 | nc_intron | 0 | −0.021 | .02746 | |
| chr17 | 44652266 | 44652511 | 2 | 1.18E-05 | .02301 | ABI3 | Exon;intron | 0 | −0.014 | .002791 | |
| chr17 | 70268887 | 70268897 | 2 | 9.75E-07 | .04621 | SLC9A3R1 | Intron;nc_intron | 11,350 | −0.017 | .005602 | |
| chr17 | 77226056 | 77226266 | 4 | 4.00E-06 | .00921 | TSPAN10 | nc_exon;utr3 | 0 | −0.031 | ||
| chr17 | 77986792 | 77986955 | 4 | 1.35E-05 | .03938 | HEXDC | Exon;intron | 0 | −0.011 | .0008078 | |
| chr17 | 78474047 | 78474241 | 3 | 1.15E-06 | .00288 | TBCD | Intron | 0 | −0.013 | ||
| chr19 | 1207998 | 1208217 | 3 | 1.38E-05 | .03013 | MIDN | Exon | 0 | −0.007 | ||
| chr19 | 10523581 | 10523782 | 5 | 1.46E-05 | .03466 | ATG4D | Exon;intron;nc_ exon;nc_intron; utr5 |
3,012 | −0.008 | ||
| chr19 | 18121329 | 18121515 | 4 | 3.31E-08 | 8.64E-05 | MAST3 | Exon | 0 | −0.016 | ||
| chr19 | 55911909 | 55912349 | 9 | 1.02E-07 | .00011 | SHANK1 | Exon;utr5 | 0 | −0.008 | 7.29E-06 | |
| chr19 | 60006690 | 60006895 | 6 | 3.44E-06 | .00812 |
KIR2DL4; KIR2DS2; KIR3DL1 |
Intron;utr5 | 12,754 | −0.012 | ||
| chr20 | 34937784 | 34937967 | 4 | 1.33E-06 | .00353 | C20orf118 | 17 | 11,603 | −0.008 | ||
| chr20 | 55416108 | 55416384 | 3 | 3.23E-06 | .00566 | RBM38 | Exon;utr3 | 0 | −0.012 | .0143 | |
| chr21 | 46670037 | 46670291 | 4 | 1.79E-09 | 3.42E-06 | PCNT | Exon;intron | 0 | −0.021 | .00112 | |
| chr22 | 45064135 | 45064392 | 4 | 3.11E-09 | 5.88E-06 | TTC38 | Exon;intron | 0 | −0.023 |