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. 2015 Mar 18;6(14):11806–11819. doi: 10.18632/oncotarget.3688

Figure 2. Effects of STS in combination with chemotherapy on viability and glucose uptake by colon carcinoma cells.

Figure 2

Tumor cells were cultured in with either low glucose (0.5 g/l) and 1% serum (in vitro STS) or the standard glucose levels (1.0 g/l) and 10% serum (control) for 48 hours. Then, cells were incubated with 40 μM oxaliplatin (OXP) for 24 hours. Panel A shows cell viability of different mouse and human colon carcinoma cell lines (CT26, HCT 116 and HT-29) as determined by Trypan Blue Assay. Panel B shows 18F-Fluorodeoxyglucose (FDG) uptake by different colon carcinoma cells (CT26, HCT 116 and HT-29). Tumor cells were incubated with FDG at 37 KBq/ml for 60 minutes. FDG retention was measured as the ratio between bound and total radioactivity. Data are expressed as percentage of viable cells ± SD. P value was calculated using unpaired t-test with Welch's correction. *: P<0.05; **: P<0.01; ***: P<0.001.