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. 2015 Apr 25;6(14):11863–11881. doi: 10.18632/oncotarget.3787

Figure 1. Absence of JNK2 accelerates pubertal mammary development and alters mammary cell differentiation.

Figure 1

A. Representative whole mounts of mammary glands from jnk2wt and jnk2ko mice at puberty (5 wk-old); B-D. Quantification of ductal extension, branching, and total terminal end buds from pre-puberty (3wk-old) and puberty (n = 5); E-F. Quantification of p63+ basal cells and ER+ luminal cells in adult ducts (n = 3); G. Western blot of CK8/18 expression in adult mammary organoids; H. Representative CD24 and CD49f staining of adult mammary cells; I-J. Representative images of Smooth Muscle Actin (SMA)+ and CK8/18+ in 3D cultures. Nonparametric t-tests were performed for all analyses except Linear Regression analysis was used for D. *p < 0.05, **p < 0.001, ***p < 0.0001.