Skip to main content
. 2015 Apr 14;6(14):12080–12093. doi: 10.18632/oncotarget.3813

Figure 2. Gene expression analysis of cell cycle regulators in malignant and benign mouse MTC by RT-qPCR.

Figure 2

Relative mRNA expression of A) CDK genes, Cdk1, Cdk2, Cdk4, Cdk5 and Cdk6; B) cyclin genes, Ccna1, Ccnb1, Ccne1, Ccne2, Ccnd1, and Cdk5r1 and C) CKI genes, Cdkn2a, Cdkn2c, Cdkn2d, Cdkn1a, Cdkn1b and Cdkn2b in proliferating malignant (P) versus arrested benign NSE/p25-GFP mouse tumors. P-values are p < 0.0001 for Cdk1, Cdk2, Cdk4, Cdk6, p = 0.9838 for CDK5; p < 0.0001 for Ccna1, Ccnb1, Ccnd1, Ccne1 and Ccne2, p = 0.0057 for Cdk5r1; p = 0.1754 for Cdkn2b, p = 0.005 for Cdkn2a, p = 0.0052 for Cdkn2c, p = 0.0003 for Cdkn2d, p < 0.0001 for Cdkn1a and p = 0.0811 for Cdkn1b. Data are represented as mean +/− SEM, N = 6-7 for each condition.