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. 2015 Apr 14;6(14):12080–12093. doi: 10.18632/oncotarget.3813

Figure 3. Evaluation of the effects of p25-GFP overexpression on cell cycle protein expression in malignant versus benign mouse MTC.

Figure 3

Immunoblots of lysates from proliferating malignant (P) and arrested benign (A) mouse MTC for A) CDK2, CDK4 and CDK6; B) cyclins A1, B1, D1, E2 and C) p15INK4b, p16INK4a, p18INK4c, p19INK4d, p21CIP/WAF1 and p27KIP. P-values are p < 0.0001 for CDK2, p = 0.6974 for CDK4, p = 0.0633 for CDK6; p < 0.0001 for cyclin-A1, p = 0.0194 for cyclin-B1, p = 0.3416 for cyclin-D1, p < 0.0001 for cyclin-E2; p = 0.0002 for p15INK4b, p = 0.291 for p16INK4a, p = 0.0006 for p18INK4c, p = 0.0054 for p19INK4d, p = 0.02 for p21CIP/WAF and p = 0.67 for p27KIP1. Data are represented as mean +/− SEM, N = 6 for each condition.