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. 2015 Mar 26;6(14):12110–12127. doi: 10.18632/oncotarget.3661

Figure 3. MiRNA profiling of melanoma samples.

Figure 3

A) Heatmap of whole miRNome qPCR array data of all 44 samples (see Fig. 1) normalized by global plate mean (miRNAs absent across all samples are not depicted). WB: whole blood, NS: normal skin tissue, MET: metastatic tissue, PM: primary melanoma tissue, st: stage; NHEK: normal human epidermal keratinocyte cell line; NHEM: normal human epidermal melanocyte cell line, HY: healthy, HYcd: healthy circadian, MP: melanoma patient, HP: healthy pool, PP: patient pool. * represent normal skin, arrows metastatic tissue and “P” indicates primary tumour. B) Heatmap and C) PCA and t-SNE plots of 82 individual serum samples (30 healthy volunteers and 52 melanoma patients) analysed by custom qPCR arrays. Data were normalized using the 5 most stable miRNAs. Colours: blue-male; pink-female; green-healthy; red-patient.