Skip to main content
. 2015 Mar 30;6(14):12279–12296. doi: 10.18632/oncotarget.3733

Figure 2. Differential mitochondrial fuel of IDH1 mutant cells.

Figure 2

A. Representative micrograph of the utilization patterns of 8 different mitochondrial substrates in IDH1+/+ and R132H/+ cells cultured in the absence or presence of graded concentrations of metformin for 48 h. The hexose D-galactose is metabolized to NADH via mitochondrial activity, whereas α-D-glucose can bypass these mitochondrial functions. Glucose-1-phosphate is metabolized differently from glucose and galactose, whereas ribose-containing inosine and xylitol are both metabolized (albeit differently) via the pentose phosphate pathway. αKG directly enters the TCA cycle, whereas the ketones β-hydroxybutyrate and pyruvic acid enter the TCA cycle upon metabolism and linkage to coenzyme A. B. Representative micrographs of the utilization patterns of 8 different mitochondrial substrates in IDH1+/+ and R132H/+ cells cultured in the absence or presence of graded concentrations of phenformin (top) or AICAR (bottom) for 48 h.