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. 2015 Mar 26;6(14):12357–12368. doi: 10.18632/oncotarget.3657

Figure 1. Expression of PAQR3 is reduced in human breast cancer samples and inversely correlated with HER2 expression.

Figure 1

The relative level of PAQR3 mRNA in human breast cancer tissues in comparison with PCHNT specimen from 82 breast cancer patients is shown in (A) PAQR3 mRNA level was determined by quantitative RT-PCR and adjusted for GAPDH. The relative ratio of PAQR3 mRNA in the cancer samples vs PCHNT samples is shown in (B). The tumor/PCHNT ratio < 0.5 is considered as low expression. The correlation of PAQR3 mRNA level with HER2 expression is shown in (C). IHC was used to determine the protein expression level of HER2. The IHC score of HER2 is plotted with the mRNA level of PAQR3. Note that PAQR3 expression level is inversely correlated with HER2 expression level.