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. 2015 Mar 26;6(14):12357–12368. doi: 10.18632/oncotarget.3657

Figure 6. Inhibition of HER2 elevates PAQR3 expression in SKBR3 cells.

Figure 6

(A, B) Effect of PAQR3 on HER2 expression. The mRNA levels of PAQR3 and HER2 were measured by quantitative RT-PCR in SKBR3 cells infected with lentivirus that had overexpression of PAQR3 or knockdown of PAQR3 by a PAQR3-specific shRNA. (C) Inhibition of HER2 increased PAQR3 expression. SKBR3 cells were treated with various concentrations of trastuzumab for 72 hours before analysis of PAQR3 mRNA level by quantitative RT-PCR. All the data are shown as mean ± SD and * for P < 0.05 and ** for P < 0.01 as compared to the control group.