Table 2. Univariate and multivariate analyses of survival of 82 patients with breast cancers.
| DFS | OS | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n | Survival | Univariate analysis | Multivariate analysis | Survival | Univariate analysis | Multivariate analysis | ||||||
| (months) | χ2 | P | HR (95% CI) | P | (months) | χ2 | P | HR (95% CI) | P | |||
| Age (years) | ||||||||||||
| <50 | 50 | 74.2 | 0.026 | 0.873 | 1.217（0.453-3.268） | 0.697 | 92.6 | 0.004 | 0.948 | 1.440（0.797-2.603） | 0.227 | |
| ≥50 | 32 | 71.8 | 88.5 | |||||||||
| Tumour size | ||||||||||||
| ≤2 cm | 39 | 79.4 | 2.812 | 0.094 | 1.549（0.587-4.090） | 0.377 | 95.4 | 1.022 | 0.312 | 1.530（0.870-2.693） | 0.140 | |
| >2 cm | 43 | 67.6 | 86.0 | |||||||||
| T stage | ||||||||||||
| I/II | 67 | 74.1 | 0.077 | 7.821E-01 | 0.636（0.155-2.609） | 0.530 | 92.9 | 0.014 | 0.906 | 0.522（0.226-1.208） | 0.129 | |
| III/IV | 15 | 71.2 | 85.9 | |||||||||
| Lymph node metastasis | ||||||||||||
| Negative | 38 | 83.6 | 5.317 | 0.021 | 1.223（0.384-3.893） | 0.733 | 97.7 | 1.149 | 0.284 | 1.553（0.799-3.016） | 0.194 | |
| Positive | 44 | 64.7 | 84.4 | |||||||||
| TNM stage | ||||||||||||
| I/II | 55 | 80.1 | 4.094 | 0.043 | 1.490（0.414-5.360） | 0.542 | 96.3 | 1.252 | 0.263 | 1.321（0.631-2.768） | 0.460 | |
| III/IV | 27 | 60.1 | 81.5 | |||||||||
| PAQR3 | ||||||||||||
| Normal/high | 24 | 95.9 | 22.258 | 2.383E-06 | 2.776（0.760-10.133） | 0.122 | 97.9 | 3.042 | 0.081 | 7.334（2.839-18.947） | 3.870E-05 | |
| Low | 58 | 64.1 | 88.0 | |||||||||
Note: PAQR3 mRNA low expression is defined as tumor/PCHNT < 0.5 and normal/high expression as tumor/PCHNT >= 0.5.