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. 2015 Mar 8;6(14):12468–12480. doi: 10.18632/oncotarget.3487

Figure 1. The effect of T1 local radiation on the growth of T2 tumors in the absence or presence of systemic CTLA-4 blockade.

Figure 1

A) The growth of primary and secondary tumors in sequential models. At day 10 after tumor cell injection of the primary site, the secondary tumor was challenged. LRT 5Gy was initiated on day 5 after tumor challenge onto the right thigh, and CTLA-4 blockade with its monoclonal antibody was given after completion of radiation (left diagram). The growth of primary (T1) and secondary tumor (T2) was shown in the middle and right panel, respectively. B) The growth of local and distant tumors in concurrent models. Two tumors T1 and T2 were challenged concurrently on day 0. Treatment schedule was shown in the diagram (bottom panel) and effect on tumor growth was shown in the top and middle panels. * represents comparison with untreated group and # represents comparison with LRT alone group, respectively.