Table 2. Results of multivariate Cox proportional-hazards analysis in testing set.

Variable	For death			For recurrence-free survival
	Hazard Ratio	95% confidence interval	p	Hazard Ratio	95% confidence interval	p
Age <50.00 years (VS. ≥50years)	0.558	0.297 to 1.050	0.07	0.558	0.297 to 1.047	0.069
Gender male (VS. female)	0.774	0.263 to 2.276	0.642	0.752	0.255 to 2.215	0.605
Clinical stage IV+III (VS. II+I)	3.467	1.197 to 10.037	0.022	3.289	1.136 to 9.527	0.028
Tumor size ≤5.0cm	1.366	0.656 to 2.843	0.404	1.339	0.646 to 2.777	0.432
(VS.>5.0cm)
AFP <200ng/mL (VS. ≥200ng/mL)	1.149	0.514 to 2.573	0.735	1.127	0.504 to 2.520	0.771
Edmonson grade	5.075	2.052 to 12.551	0	5.001	2.013 to 12.424	0.001
Low (vs.high)
Tumor number solitary (vs. mutiple)	1.072	0.539 to 2.134	0.842	10.6	0.534 to 2.106	0.867
USP22 Positive (vs. negative)	4.973	2.115 to 11.693	0	4.943	2.100 to 11.636	0