Table 3. Results of multivariate Cox proportional-hazards analysis in overall patients.

Variable	For death			For recurrence-free survival
	Hazard Ratio	95% confidence interval	p	Hazard Ratio	95% confidence interval	p
Age <50.00 years (VS. ≥50years)	0.55	0.347 to 0.872	0.011	0.549	0.347 to 0.870	0.011
Gender male (VS. female)	1.056	0.430 to 2.596	0.905	0.549	0.347 to 0.870	0.011
Clinical stage IV+III (VS. II+I)	3.537	1.626 to 7.692	0.001	1.044	0.425 to 2.564	0.926
Tumor size ≤5.0cm	1.403	0.819 to 2.401	0.217	3.501	1.608 to7.623	0.002
(VS.>5.0cm)
AFP <200ng/mL (VS. ≥200ng/mL)	1.18	0.643 to 2.165	0.593	1.379	0.807 to 2.356	0.24
Edmonson grade	3.854	1.998 to 7.437	0	1.18	0.645 to 2.161	0.591
Low (vs.high)
Tumor number solitary (vs. mutiple)	0.901	0.531 to 1.529	0.699	3.847	1.992 to 7.431	0
USP22 Positive (vs. negative)	4.981	2.630 to 9.434	0	0.892	0.526 to 1.514	0.673