Skip to main content
. 2015 Mar 30;6(14):12668–12681. doi: 10.18632/oncotarget.3706

Figure 5. Maritoclax induces a loss of different components of the electron transport chain and an accumulation of mitochondrial ROS.

Figure 5

(A) Whole cell lysates of H460 cells, exposed to dinaciclib (30 nM), maritoclax (3 μM) or dimethoxymaritoclax (3 μM) for the indicated times, were immunoblotted with the indicated antibodies. (B) H460 cells, exposed to dinaciclib (30 nM) or maritoclax (3 μM) for the indicated times, were stained with MitosoxRed to monitor the accumulation of mitochondrial reactive oxygen species (ROS). Error bars represent the Mean ± SEM from three independent experiments.