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. 2015 Jun 30;5(1):1–8. doi: 10.14581/jer.15001

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Copyright © 2015 Korean Epilepsy Society

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Representation of different mechanisms associated with resistance development in epilepsy (A) shows the normal activity of transporter protein (P-gp transporter) and sufficient concentration at target site; (B) shows the over-expression of transport protein leading reduced concentration of AEDs at target site; (C) represents the normal target protein orientation and hence good efficacy of AEDs (D) represents the modified orientation of target protein leading inefficacy of AEDs; (E) represents overall mechanisms for the development of pharmacoresistance in epilepsy.