Table 4.

Reactions of barbituric acids 1a, 1b, heteroaromatic aldehydes 2e, 2f, and malononitrile 9 in the reaction conditions E–H

Entry	Reagent	R	Reagent	R	Method	Reagent	R	Product		Yield/% of 3
								10	3
1	1a	CH3	2e	2-Thienyl	E	9	–	–	3e	–
2	1a	CH3	2e	2-Thienyl	F	9	–	–	3e	–
3	1a	CH3	2e	2-Thienyl	G	9	–	–	3e	89
4	1a	CH3	2e	2-Thienyl	H	9	–	–	3e	93
5	2e	2-Thienyl	9	–	E	1a	CH3	10a	3e	91
6	2e	2-Thienyl	9	–	F	1a	CH3	10a	3e	85
7	1b	H	2e	2-Thienyl	E	9	–	–	3f	–
8	1b	H	2e	2-Thienyl	F	9	–	–	3f	–
9	1b	H	2e	2-Thienyl	G	9	–	–	3f	85
10	1b	H	2e	2-Thienyl	H	9	–	–	3f	89
11	2e	2-Thienyl	9	–	E	1b	H	10a	3f	90
12	2e	2-Thienyl	9	–	F	1b	H	10a	3f	81
13	1a	CH3	2f	2-Furyl	E	9	–	–	3g	–
14	1a	CH3	2f	2-Furyl	F	9	–	–	3g	–
15	1a	CH3	2f	2-Furyl	G	9	–	–	3g	87
16	1a	CH3	2f	2-Furyl	H	9	–	–	3g	90
17	2f	2-Furyl	9	–	E	1a	CH3	10b	3g	88
18	2f	2-Furyl	9	–	F	1a	CH3	10b	3g	79