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Levels of striatal D2/D3R BPND in CNBP patients and HCs. Significant reductions in D2/D3R BPND, compared with HC sample, were observed at baseline in the right ventral striatum. A, Top, Significant region in the ventral striatum and plots of average D2/D3R BPND values for HC subjects (empty circles) and CNBP patients (filled circles). The D2/D3R BPND in this region was negatively correlated with positive affect and pain tolerance measures in CNBP patients (B, bottom).
