Table 3. Ciprofloxacin resistant strains of P. aeruginosa used in this study and MICs of the four antibiotics selected as markers for Beta-lactams [Imipenem (IMI) & Cefepime (CEF)], Fluoroquinolones [Ciprofloxacin (CIP)] and Aminoglycosides [Gentamicin (GEN)] tested in the absence or in the presence of the efflux inhibitor CCCP.
Strains | MIC (mg/L) | |||||||
---|---|---|---|---|---|---|---|---|
IMI | CEF | CIP | GEN | |||||
-CCCP | +CCCP | -CCCP | +CCCP | -CCCP | +CCCP | -CCCP | +CCCP | |
208 | 256 | 4 | 1,024 | 0.5 | 128 | 0.5 | 4 | 2 |
209 | 128 | 4 | 1,024 | 0.5 | 128 | 0.5 | 1,024 | 1 |
211 | 256 | 4 | 1,024 | 0.5 | 128 | 0.5 | 1,024 | 1 |
212 | 256 | 2 | 1,024 | 0.5 | 128 | 0.5 | 1,024 | 1 |
215 | 256 | 8 | 1,024 | 8 | 128 | 0.5 | 1,024 | 1 |
322 | 128 | 128 | 1,024 | 0 | 128 | 0.5 | 32 | 1 |
477 | 256 | 4 | 512 | 512 | 8 | 0.5 | 256 | 128 |
481 | 32 | 8 | 64 | 32 | 16 | 2 | 1,024 | 512 |
483 | 32 | 8 | 64 | 64 | 16 | 1 | 1,024 | 512 |
488 | 128 | 8 | 64 | 32 | 16 | 0.5 | 128 | 64 |
517 | 256 | 128 | 1,024 | 512 | 8 | 0.5 | 256 | 256 |
520 | 256 | 128 | 1,024 | 1,024 | 16 | 0.5 | 256 | 256 |
529 | 128 | 64 | 512 | 256 | 16 | 0.5 | 128 | 16 |
538 | 256 | 256 | 1,024 | 512 | 16 | 0.5 | 256 | 128 |
539 | 64 | 4 | 512 | 256 | 16 | 0.5 | 128 | 128 |
599 | 128 | 64 | 1,024 | 64 | 16 | 0.5 | 128 | 64 |
PAO1 | 2 | 2 | 0.5 | 0.5 | 1 | 1 | 2 | 2 |
-CCCP, in the absence of carbonyl cyanide-m-chlorophenylhydrazone; +CCCP, in the presence of carbonyl cyanide-m-chlorophenylhydrazone.