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(A) A multiple sequence alignment including the LAP2alpha domains of mammalian LAP2α and ZNF451-L2a and homologous sequences from non-mammalian DIRS1-like elements. The phylogenetic tree in (B) was built with Phyml for the LAP2alpha domains of LAP2α and ZNF451-L2a. Overall dN/dS ratios were calculated with the SLAC method in DataMonkey (see Supplementary Appendix). (C) A schematic structure of the DIRS1-like element from which the LAP2alpha domain originated
