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Lissencephaly. Cortical malformations result from abnormal neuronal migration during the early stages of neurogenesis. The extensively thickened cortex typically only consists of four disorganized layers. Consistent with the clinical picture of lissencephaly (Budday et al., 2014a) (top right), the numerical simulation (Budday et al., 2014b) (bottom right) predicts the absence of folds for extensively thickened cortices.
