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. 2015 May 29;22(8):1250–1259. doi: 10.1038/cdd.2015.67

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Copyright © 2015 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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EBOV infection induces innate immune cell dysfunctions. (a) EBOV infection is able to impair type-I IFNs production by infected cells and to block IFN response in uninfected cells; (b) EBOV infection is able to induce massive cytokines/chemokines production by monocytes/macrophages; (c) EBOV infection is able to impair DC maturation and to deregulate cytokine production. (d) EBOV infection is able to induce massive NK apoptosis, thus avoiding NK function and impairing NK-mediated DC maturation help