Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Jun 15;29(12):1285–1297. doi: 10.1101/gad.264234.115

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2015 Chen et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

PMC Copyright notice

Figure 7. — Feedback activation of Hippo signaling protects against developmental defects in the Yap^S112A animals. (A) Gross appearance of livers and quantification of liver/body weight ratio of Nf2^flox^/flox and Nf2^flox^/flox; Yap^S112A/S112A mice 8 wk after Ad-Cre injection. Data are mean ± SD from five animals of each genotype. (*) P < 0.05, t-test. Bar, 1 cm. (B) H&E, pan-CK, and phospho-Histone H3 (PH3) staining of liver sections from Nf2^flox^/flox and Nf2^flox^/flox; Yap^S112A/S112A littermates 8 wk after Ad-Cre injection. Note the increased BEC proliferation in Nf2^flox^/flox; Yap^S112A/S112A mutant livers compared with those of Nf2^flox^/flox mutant livers. Bar, 100 µm. (C) Western blot analysis of liver protein lysates from wild-type, Yap^S112A^/S112A, Nf2^flox^/flox and Nf2^flox^/flox; Yap^S112A/S112A mice 2 mo after Ad-Cre injection. The graph shows quantification of YAP relative to tubulin from the four genotypes. Data are mean ± SD from three animals for each genotype. (*) P < 0.05, t-test.