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. 2015 Jun 15;29(12):1316–1325. doi: 10.1101/gad.265462.115

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© 2015 Cao et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 3. — Comparison of resveratrol-binding modes. (A) A surface representation (with electrostatic potential distribution) of SIRT1 with the bound p53-AMC peptide and resveratrol. The NTD of SIRT1 was removed for viewing clarity. (B) The structure of SIRT5 with the bound peptide and resveratrol (Protein Data Bank [PDB] ID 4HDA). (C) The structure of SIRT3 with the bound peptide and bromo-resveratrol (PDB ID 4C7B). (D) The structure of SIRT3 with the bound piceatannol (PDB ID 4HD8). Both the peptides (carbon colored gold) and resveratrol or its analog (carbon colored green) are shown as a stick model.