Figure 2. In vivo anti-tumor effects of compound 331.
(a, b) Inhibition of mammary tumor growth by compound 331 treatment. Experiments were carried out using 6 week old female nude mice (BALB/c-nu), when tumor sizes had grown to about 50 mm3, compound 331 (10 mg/kg, 40 mg/kg, 80 mg/kg, 0.9% saline as control) was intragastricly administrated daily for three weeks. (c) Effects of compound 331 on the volume of human tumor xenografts. (d) Effects of compound 331 on the tumor growth rate. (e) Effects of compound 331 on the weights of human tumor xenografts. (f) Effects of compound 331 on the weights of the nude mice. (g) The H&E staining of sections from hearts, livers, spleens, kidneys and brains in control group and nude mice treated with compound 331 (10 mg/kg, 40 mg/kg and 80 mg/kg) for 21 days. Scale bar: 10 μm. (c–f) Data represents the mean ± S.E.M. (n = 8). **p < 0.01 compared with control.