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. 2015 Jul 8;5:11759. doi: 10.1038/srep11759

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Copyright © 2015, Macmillan Publishers Limited

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TGFβ-treated cells generate traction forces which are required to remodel the extracellular matrix and to disseminate in 2/3D environment. This requires the activation of the Rho/ROCK pathway and actomyosin function. The Ral pathway controls the dissemination of TGFβ-treated cells by modulating RhoA-dependent actomyosin contractility via the interaction between the Sec5 subunit of Exocyst and the RhoGEF GEF-H1.