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. 2015 Jul 8;5:11717. doi: 10.1038/srep11717

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Copyright © 2015, Macmillan Publishers Limited

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(A) and fungal burden (B,C) after infection of mice with serotype C isolates of C. gattii. A. Mice infected with the ATCC 24066 isolate lived longer than those infected with isolates 106.97 and WM 779 (P = 0.0003). B. Pulmonary burden after infection with isolate ATCC 24066 was always smaller (P<0.05) in comparison with systems where animals were inoculated with isolates 106.97 or WM 779. C. Brain colonization after infection of mice with isolates 106.96 and WM 779. Isolate WM 779 took longer to infect the brain of mice, but fungal burden 21 days post-infection was significantly higher for this isolate. Negative results were obtained when fungal colonization was analyzed after infection with isolate ATCC 24066. Isolate 106.97, blue bars; isolate WM 779, orange bars.