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. 2015 Jul 8;5:12175. doi: 10.1038/srep12175

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(a) Efficacy of cisplatin treatment on T47D cell monolayer cultures. When the T47D cells were cultured with media + FBS rather than conditioned media (CM), the IC50 was estimated to be 23.5 μM. However, with fibroblast CM, the IC50 increased to 67.5 μM (N = 5 cultures), verifying that the fibroblast conditioned media can boost chemodrug resistance. (b) Efficacy of PDT on 2D monolayer cell cultures with and without fibroblast conditioned media. No significant difference was observed between the two culture conditions. (c) The efficacy of PDT on 3D large spheres with and without the fibroblast conditioned media. No significant difference was observed between the two culture conditions. * refers to P < 0.05, and ** refers to P < 0.01.