Table 2.

BRCA1 and BRCA2 mutations in women with breast cancer in Mexico City, Monterrey and Veracruz, 2007–2010

Case	Gene	Exon	Mutation	Codon Change	HGVS nomenclature	AGE	STAGE	HISTOLOGY	FAM HX BR CA
D2062	BRCA1	9–12	del	14.7kb deletion	c.548?_4185 ?del	44	Missing	Ductal	Yes
D2073	BRCA1	9–12	del	14.7kb deletion	c.548?_4185 ?del	35	Missing	Ductal	No
M1209	BRCA1	9–12	del	14.7kb deletion	c.548?_4185 ?del	43	II	Ductal	No
M1761	BRCA1	9–12	del	14.7kb deletion	c.548?_4185 ?del	46	III	Ductal	No
M1916	BRCA1	9–12	del	14.7kb deletion	c.548?_4185 ?del	43	III	Ductal	No
M1954	BRCA1	9–12	del	14.7kb deletion	c.548?_4185 ?del	44	I	Ductal	Yes
V3044	BRCA1	9–12	del	14.7kb deletion	c.548?_4185 ?del	56	I	Ductal	Yes
V3236	BRCA1	9–12	del	14.7kb deletion	c.548?_4185 ?del	37	Missing	Missing	No
D2309	BRCA1	11	1135insA	Stop 345	c.1016–1017insA	41	Missing	Medullary	No
M1956	BRCA1	11	2190delA	Stop 700	c.2071-2071delA	51	II	Ductal	No
M2255	BRCA1	11	2415delAG	Stop 766	c.2296–2297delAG	34	II	Ductal	No
D2058	BRCA1	11	2552delC	Stop 814	c.2433delC	50	Missing	Not classified	No
D2142	BRCA1	11	2552delC	Stop 814	c.2433delC	38	I	Ductal	No
M2273	BRCA1	11	C3717T	Q1200X	c.3598C>T	39	Missing	Ductal	No
M1607	BRCA1	13	C4446T	R1443X	c.4327C>T	50	II	Ductal	No
V3053	BRCA1	13	C4446T	R1443X	c.4327C>T	38	I	Ductal	No
D2090	BRCA1	18	C5242A	A1708E	c.5123C>A	42	Missing	Ductal	No
D2377	BRCA1	18	C5242A	A1708E	c.5123C>A	39	I	Medullary	No
M1738	BRCA1	18	C5242A	A1708E	c.5123C>A	70	II	Not classified	No
M1895	BRCA1	18	C5242A	A1708E	c.5123C>A	49	III	Ductal	No
V3267	BRCA2	10	2024del5	Stop 599	c.1796–1800delTTTAT	53	III	Ductal	No
V3319	BRCA2	10	2024del5	Stop 599	c.1796–1800delTTTAT	39	II	Ductal	No
V3054	BRCA2	10	2024del5	Stop 599	c.1796–1800delTTTAT	54	II	Lobular	No
V3054	BRCA2	11	4321insAA	N/A	N/A	54	II	Lobular	No
M1768	BRCA2	11	2971del5	N/A	N/A	45	III	Ductal	No
M2251	BRCA2	11	3036del4	Stop 959	c.2808–2811delACAA	48	Missing	Ductal	Yes
M1193	BRCA2	11	3492insT	Stop 1098	c.3264–3265insT	63	II	Not classified	No
D2379	BRCA2	11	4534delAT	N/A	N/A	51	III	Lobular	No
M1911	BRCA2	11	5770delA	Stop 1862	c.5542delA	42	III	Ductal	Yes
M1831	BRCA2	11	5859delC	N/A	N/A	56	II	Ductal	No
V3269	BRCA2	11	6686delC	P2153L	N/A	43	III	Ductal	No
M1894	BRCA2	11	6714delACAA	Stop 2166	c.6486–6489delACAA	56	III	Ductal	No
M1349	BRCA2	11	C4339T	Q1371X	c.4111C>T	39	III	Ductal	No
M1751	BRCA2	11	C4339T	Q1371X	c.4111C>T	75	II	Lobular	No
V3220	BRCA2	11	C4339T	Q1371X	c.4111C>T	52	Missing	Ductal	No

Abbreviations: HGVS= Human Genome Variation Society; FAM HX BR CA= family history of breast cancer