Table 3.
Characteristics of breast cancer cases by BRCA1/2 mutation status in Mexico City, Monterrey and Veracruz, 2007–2010
| Characteristics | Total | Non carrier | BRCA 1 | BRCA 2 | P valuea | ||||
|---|---|---|---|---|---|---|---|---|---|
| n | n = 810 | n = 775 | n = 20 | n = 15 | |||||
| Age (years) | |||||||||
| Median | 51.5 | 52 | 43 | 50.9 | |||||
| Interquartile range | (44.7, 59.4) | (44.9, 59.7) | (38.3, 49.4) | (42.5, 56.2) | <0.001 | ||||
| European Ancestry, n (%)b | |||||||||
| <25% | 227 | (28.0) | 217 | (28.0) | 6 | (30.0) | 4 | (26.7) | |
| 25–50% | 353 | (43.6) | 336 | (43.4) | 11 | (55.0) | 6 | (40.0) | |
| 51–75% | 146 | (18.0) | 140 | (18.1) | 2 | (10.0) | 4 | (26.7) | |
| 76–100% | 19 | (2.3) | 19 | (2.5) | 0 | (0.0) | 0 | (0.0) | 0.898 |
| Breast cancer histology, n (%)b | |||||||||
| Ductal | 499 | (61.6) | 473 | (61.0) | 15 | (75.0) | 11 | (73.3) | |
| Lobular | 99 | (12.2) | 96 | (12.4) | 0 | (0.0) | 3 | (20.0) | |
| Ductal in situ | 54 | (6.7) | 54 | (7.0) | 0 | (0.0) | 0 | (0.0) | |
| Mixed | 32 | (4.0) | 32 | (4.1) | 0 | (0.0) | 0 | (0.0) | |
| Not classified | 23 | (2.8) | 20 | (2.6) | 2 | (10.0) | 1 | (6.7) | |
| Medullary | 7 | (0.9) | 5 | (0.6) | 2 | (10.0) | 0 | (0.0) | |
| Mucinous | 4 | (0.5) | 4 | (0.5) | 0 | (0.0) | 0 | (0.0) | |
| Lobular in situ | 3 | (0.4) | 3 | (0.4) | 0 | (0.0) | 0 | (0.0) | |
| Tubular/cribriform | 3 | (0.4) | 3 | (0.4) | 0 | (0.0) | 0 | (0.0) | |
| Papillary | 3 | (0.4) | 3 | (0.4) | 0 | (0.0) | 0 | (0.0) | |
| Apocrine | 2 | (0.2) | 2 | (0.3) | 0 | (0.0) | 0 | (0.0) | |
| Non-specified non-invasive | 2 | (0.2) | 2 | (0.3) | 0 | (0.0) | 0 | (0.0) | |
| Metaplastic | 2 | (0.2) | 2 | (0.3) | 0 | (0.0) | 0 | (0.0) | 0.183 |
| Stage, n (%) | |||||||||
| 0 | 17 | (2.1) | 17 | (2.2) | 0 | (0.0) | 0 | (0.0) | |
| I | 87 | (10.7) | 82 | (10.6) | 5 | (25.0) | 0 | (0.0) | |
| II | 363 | (44.8) | 353 | (45.5) | 5 | (25.0) | 5 | (33.3) | |
| III | 178 | (22.0) | 168 | (21.7) | 3 | (15.0) | 7 | (46.7) | |
| IV | 15 | (1.9) | 15 | (1.9) | 0 | (0.0) | 0 | (0.0) | |
| Non-classifiable | 21 | (2.6) | 21 | (2.7) | 0 | (0.0) | 0 | (0.0) | 0.235 |
| History of breast cancer in first degree, n (%)c | |||||||||
| No | 752 | (92.8) | 722 | (93.2) | 17 | (85.0) | 13 | (86.7) | |
| Yes | 58 | (7.2) | 53 | (6.8) | 3 | (15.0) | 2 | (13.3) | 0.130 |
| History of cancer in first degree, n (%)b,c | |||||||||
| No | 552 | (68.1) | 535 | (69.0) | 9 | (45.0) | 8 | (53.3) | |
| Yes | 239 | (29.5) | 221 | (28.5) | 11 | (55.0) | 7 | (46.7) | 0.017 |
a
Kruskal Wallis test for continuous variables, Fisher´s exact test for categorical variables.
b
Percentages may not add up to 100% due to missing data.
c
We considered parents and siblings as first degree relatives.
d
Participants who did not know their number of siblings were excluded from the analysis.