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. 2015 Jul 8;5:11382. doi: 10.1038/srep11382

Figure 1. FGF21 improves glucose tolerance in Zucker rats.

Figure 1

Eight week old Zucker rats were administered vehicle, 1.32 mg/kg/day native FGF21, or 3 mg/kg and 10 mg/kg PF-05231023 subcutaneously twice a week for two weeks. a) body weight (BW), b) food intake, c) oral glucose tolerance test (OGTT), d) area under the curve (AUC), e) glucose infusion rate (GIR), f) basal hepatic glucose production (HGP), g) clamp hepatic glucose production, h) suppression of hepatic glucose production. n = 8–10 animals in each group. All data represented as Mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001 by one way Anova and Dunnett’s posthoc test.