Table 4. Stratified analyses of the C20orf54 rs13042395 polymorphism on cancer risk.
| Heterogeneity test | Hypothesis test | ||||||
|---|---|---|---|---|---|---|---|
| Comparisons | Q | P | I2(%) | Summary OR (95%CI) | Z | P | Studies |
| Smoking status | |||||||
| Smokers | |||||||
| T vs C | 0.95 | 0.81 | 0 | 0.98(0.89,1.08) | 0.34 | 0.73 | 4 |
| CT vs CC | 11.38 | 0.01 | 74 | 0.90(0.66,1.22) | 0.68 | 0.49 | 4 |
| TT vs CC | 1.92 | 0.59 | 0 | 1.00(0.79,1.27) | 0.02 | 0.99 | 4 |
| CT + TT vs CC | 4.79 | 0.19 | 37 | 0.96(0.85,1.08) | 0.70 | 0.48 | 4 |
| TT vs CT + CC | 5.62 | 0.13 | 47 | 1.06(0.84,1.33) | 0.50 | 0.62 | 4 |
| Never smokers | |||||||
| T vs C | 3.47 | 0.33 | 13 | 1.00(0.94,1.06) | 0.11 | 0.91 | 4 |
| CT vs CC | 0.30 | 0.96 | 0 | 0.95(0.87,1.02) | 0.35 | 0.18 | 4 |
| TT vs CC | 1.13 | 0.77 | 0 | 0.97(0.84,1.11) | 0.44 | 0.66 | 4 |
| CT + TT vs CC | 0.52 | 0.91 | 0 | 0.94(0.87,1.02) | 1.56 | 0.12 | 4 |
| TT vs CT + CC | 14.63 | <0.01 | 79 | 1.13(0.76,1.67) | 0.61 | 0.54 | 4 |
| Drinking status | |||||||
| Drinkers | |||||||
| T vs C | 0.36 | 0.95 | 0 | 0.98(0.88,1.10) | 0.27 | 0.19 | 4 |
| CT vs CC | 12.86 | 0.01 | 77 | 0.83(0.56,1.22) | 0.96 | 0.34 | 4 |
| TT vs CC | 0.59 | 0.90 | 0 | 0.99(0.75,1.31) | 0.06 | 0.96 | 4 |
| CT + TT vs CC | 4.62 | 0.20 | 35 | 0.95(0.82,1.10) | 0.65 | 0.51 | 4 |
| TT vs CT + CC | 4.75 | 0.19 | 37 | 1.07(0.82,1.40) | 0.53 | 0.60 | 4 |
| Never drinkers | |||||||
| T vs C | 1.02 | 0.80 | 0 | 0.96(0.90,1.01) | 1.61 | 0.11 | 4 |
| CT vs CC | 0.88 | 0.83 | 0 | 0.95(0.88,1.02) | 1.38 | 0.17 | 4 |
| TT vs CC | 0.67 | 0.88 | 0 | 0.92(0.81,1.05) | 1.22 | 0.22 | 4 |
| CT + TT vs CC | 1.05 | 0.79 | 0 | 0.94(0.88,1.01) | 1.59 | 0.11 | 4 |
| TT vs CT + CC | 0.43 | 0.93 | 0 | 0.94(0.83,1.07) | 0.87 | 0.39 | 4 |
| BMI | |||||||
| Under weight | |||||||
| T vs C | 0.58 | 0.75 | 0 | 0.87(0.77,0.98) | 2.26 | 0.02 | 3 |
| CT vs CC | 0.38 | 0.83 | 0 | 0.91(0.77,1.08) | 1.06 | 0.29 | 3 |
| TT vs CC | 0.66 | 0.72 | 0 | 0.70(0.52,0.93) | 2.42 | 0.02 | 3 |
| CT + TT vs CC | 1.95 | 0.38 | 0 | 0.89(0.76,1.05) | 1.41 | 0.16 | 3 |
| CC vs CT + TT | 1.48 | 0.48 | 0 | 0.74(0.56,0.98) | 2.07 | 0.04 | 3 |
| Normal weight | |||||||
| T vs C | 0.69 | 0.71 | 0 | 0.85(0.80,0.91) | 4.76 | <0.01 | 3 |
| CT vs CC | 3.95 | 0.14 | 0 | 0.82(0.75,0.89) | 4.49 | <0.01 | 3 |
| TT vs CC | 0.74 | 0.69 | 0 | 0.76(0.69,0.85) | 3.35 | <0.01 | 3 |
| CT + TT vs CC | 1.49 | 0.47 | 0 | 0.81(0.75,0.88) | 4.90 | <0.01 | 3 |
| CC vs CT + TT | 0.55 | 0.76 | 0 | 0.93(0.74,1.16) | 0.67 | 0.50 | 3 |
| Brought forward | |||||||
| Over weight | |||||||
| T vs C | 2.62 | 0.27 | 24 | 1.03(0.88,1.21) | 0.38 | 0.70 | 3 |
| CT vs CC | 0.70 | 0.71 | 0 | 1.02(0.82,1.26) | 0.19 | 0.85 | 3 |
| TT vs CC | 3.46 | 0.18 | 42 | 1.06(0.73,1.54) | 0.31 | 0.76 | 3 |
| CT + TT vs CC | 1.17 | 0.56 | 0 | 1.04(0.85,127) | 0.37 | 0.71 | 3 |
| CC vs CT + TT | 5.54 | 0.06 | 64 | 1.08(0.76,1.54) | 0.45 | 0.66 | 3 |