Table 1.
Day | Epithelialization | ||||
---|---|---|---|---|---|
CON | SSD | Vaseline | 5 % AJE | 20 % AJE | |
2 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.3 ± 0.3 | 0. 00 ± 0.00 | 0.1 ± 0.1 |
14 | 1.5 ± 0.4 | 2.3 ± 0.07 | 2.9 ± 0.1** | 2.9 ± 0.1*** | 3.0 ± 0.0** |
21 | 1.0 ± 0.0 | 2.7 ± 0.18*** | 2.9 ± 0.1*** | 2.9 ± 0.1*** | 3.0 ± 0.0*** |
Vascularization | |||||
2 | 0.0 ± 0.0 | 0.0 ± 0.0# | 1.6 ± 0.6* | 1.8 ± 0.3* | 1.6 ± 0.4* |
14 | 1.2 ± 0.4 | 1.7 ± 0.4 | 1.9 ± 0.1 | 2.2 ± 0.2 | 2.2 ± 0.2 |
21 | 1.5 ± 0.2 | 1.7 ± 0.1 | 1.9 ± 0.2 | 2.3 ± 0.3 | 2.5 ± 0.1* |
Granulation | |||||
2 | 0.0 ± 0.0 | 0.6 ± 0.1* | 1.2 ± 0.0*** | 1.5 ± 0.0*** | 1.3 ± 0.1*** |
14 | 1.4 ± 0.2 | 1.9 ± 0.1 | 2.0 ± 0.1* | 2.6 ± 0.1***,# | 2.8 ± 0.2***,# |
21 | 2.8 ± 0.0 | 2.8 ± 0.1 | 2.9 ± 0.1 | 2.9 ± 0.1 | 3.0 ± 0.1 |
Inflammation | |||||
2 | 2.6 ± 0.2 | 2.0 ± 0.1 | 2.9 ± 0.1 | 2.8 ± 0.2 | 2.7 ± 0.1 |
14 | 2.9 ± 0.1 | 2.3 ± 0.2 | 2.3 ± 0.1* | 1.3 ± 0.2***,### | 1.2 ± 0.1***, ## |
21 | 2.3 ± 0.3 | 1.3 ± 0.1* | 1.3 ± 0.1* | 0.9 ± 0.1** | 0.9 ± 0.3** |
Collagen deposition | |||||
2 | 1.2 ± 0.1 | 1.1 ± 0.2 | 1.5 ± 0.1 | 1.3 ± 0.2 | 1.1 ± 0.2 |
14 | 2.2 ± 0.2 | 2.5 ± 0.2 | 2.7 ± 0.1 | 2.8 ± 0.1* | 2.9 ± 0.1** |
21 | 2.3 ± 0.2 | 2.6 ± 0.1 | 2.7 ± 0.2 | 2.9 ± 0.1* | 3.0 ± 0.1* |
Total score | |||||
2 | 1.0 ± 0.0 | 1.4 ± 0.1 | 1.2 ± 0.0 | 1.4 ± 0.1 | 1.5 ± 0.2 |
14 | 2.1 ± 0.1 | 2.5 ± 0.1 | 2.7 ± 0.1** | 3.3 ± 0.2***, # | 3.0 ± 0.1*** |
21 | 2.4 ± 0.0 | 3.2 ± 0.1** | 3.3 ± 0.1*** | 3.6 ± 0.1*** | 3.9 ± 0.1***, # # |
Abbreviations: CON control, SSD silver sulfadiazine, AJE Ampelopsis japonica tuberous root ethanol extract. Values are expressed as mean ± standard error of the mean (n = 3–8). * P < 0.05, ** P < 0.01, *** P < 0.001 vs. Control, # P < 0.05, ## P < 0.01, ### P < 0.001 vs. Vaseline