Table 1.

Advantages and Disadvantages of Topical Oxygen.

Advantages
•Lower cost as opposed to HBO
•Home treatment option
•No complications such as middle-ear barotrauma as observed in HBOT
•No risk of systemic oxygen toxicity
•No risk of claustrophobia
•Ability to penetrate the wound directly from the surface and not from disrupted vasculature
Disadvantages
•May cause ischemia in case the pressure within the closed medium exceeds systolic pressure
•May cause vascular congestion in case the pressure within the closed medium exceeds diastolic pressure
•May not allow concurrent negative pressure wound treatment
•Does not penetrate to bone
•May cause cell toxicity