Figure 8.

Evaluation of the SPHK1 gene expression signature in human breast cancer. Agilent microarray data compiled as part of The Cancer Genome Atlas (TCGA) Project were queried for correlative gene co-expression profiles to previously identified TGFβ/Activin signaling, PAM50 and triple-negative breast cancer (TBNC) gene panels and molecular signatures. Analysis was performed using the cBioPortal (http://cbioportal.org) gateway and repository for cancer genomics data—specifically utilizing the TCGA (Nature) invasive breast cancer patient data.32,33,34,35,37