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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Curr Opin Rheumatol. 2015 Jul;27(4):357–363. doi: 10.1097/BOR.0000000000000188

Figure 2. Rheumatic disease-associated missense variants of ERAP1.

Figure 2

A surface map of ERAP1 demonstrates the locations of six rheumatic disease-associated amino acid substitutions of ERAP1 (shown as red spheres). The surface coloring indicates the domain structures (I = blue, II = green, III = orange, IV = purple) and identifies the enzyme’s catalytic site (pink), which contains the catalytic Zn2+ molecule (black sphere). This model was created using 3MDJ and PyMol software. (Courtesy of M. Ombrello)