Fig. 2.

Phylogenetic analysis of the pathogens isolated during the outbreak. A phylogenetic analysis of the nucleotide sequences of the viruses isolated during the outbreak: (a) the three partial VP1 sequences of CVA-4; (b) the near-complete nucleotide sequences of strains of human Coxsackie A virus. Phylogenetic analysis was performed and the tree was constructed using the neighbor-joining algorithm implemented in the MEGA version 5.0 software with 1000 bootstrap pseudoreplicates. The numbers on the branches indicate the bootstrap values, excluding those of < 70 % for clarity. Human rhinoviruses (HRVs) were used as outgroups on both trees. Red dots show the CV-A4 strains isolated in this study and the black dots show the only complete genome of CV-A4 in the GenBank database