Table 4.

Homozygous less functional genotypes are increased in older subjects

	Male		Female
German	Odds ratio (95 % CI)	P-value	Odds ratio (95 % CI)	P-value
TLR-6 (249S/S)	1.41 (0.98–2.04)	0.067	1.56 (0.97–2.50)	0.066
TLR-1 prom.	1.31 (0.98–1.76)	0.065	1.02 (0.70–1.48)	0.93
TLR-1 (248S/S)	1.36 (1.02–1.81)	0.038	1.31 (0.90-1.92)	0.17
TLR-1 (602S/S)	1.41 (1.06–1.87)	0.02	1.53 (1.05–2.23)	0.027
TLR-10 (775 V/V)	1.05 (0.77–1.44)	0.741	1.01 (0.69–1.54)	0.89
Lithuanian
TLR-6 (249S/S)	1.53 (0.89–2.62)	0.123	0.88 (0.65–1.89)	0.394
TLR-1 prom.	1.46 (0.91–2.36)	0.117	1.44 (1.13–1.83)	0.003
TLR-1 (248S/S)	1.42 (0.88–2.83)	0.152	2.12 (1.30–3.43)	0.002
TLR-1 (602S/S)	1.77 (1.09–2.86)	0.02	1.62 (1.04–2.53)	0.033
TLR-10 (775 V/V)	0.13 (0.36–1.14)	0.132	0.52 (0.31–0.89)	0.016
Combined
TLR-6 (249S/S)	1.54 (1.15–2.05)	0.003	1.16 (0.79–1.68)	0.44
TLR-1 prom.	1.12 (0.89–1.41)	0.34	1.41 (1.06–1.89)	0.018
TLR-1 (248S/S)	1.13 (0.89–1.42)	0.32	1.66 (1.24–2.23)	0.001
TLR-1 (602S/S)	1.18 (0.94–1.48)	0.15	1.64 (1.28–2.19)	0.001
TLR-10 (775 V/V)	0.97 (0.75–1.25)	0.79	0.73 (0.54–1.01)	0.05

Analysis was carried out by univariate logistic regression comparing the less functional homozygote genotype with the others in young versus old subjects. The reference were young subjects and the wild type + heterozygous genotype. Significant P-values below 0.05 were printed in bold