Table 3.
Selection of down-regulated genes in mouse spleens in response to MVA, LSDV, CNPV, FWPV, PEPV and FeP2. Differences in Log2 Fold Changes (between each virus and the control) are depicted
| Symbol | Name | Entrez | MVA | LSDV | CNPV | FWPV | PEPV | FeP2 |
|---|---|---|---|---|---|---|---|---|
| Genes down-regulated by LSDV ALONE | ||||||||
| Adamdec1 | ADAM-like, decysin 1 | 58860 | - | −1.1 | - | - | - | - |
| Cd59a | CD59a antigen | 12509 | - | −1.2 | - | - | - | - |
| Cd7 | CD7 antigen | 12516 | - | −1.1 | - | - | - | - |
| Esm1 | endothelial cell-specific molecule 1 | 71690 | - | −1.1 | - | - | - | - |
| Igfbp3 | insulin-like growth factor binding protein 3 | 16009 | - | −1 | - | - | - | - |
| Igk | immunoglobulin kappa chain complex | 243469 | - | −1 | - | - | - | - |
| Lilra5 | leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5 | 232801 | - | −1.1 | - | - | - | - |
| Prkcg | protein kinase C, gamma | 18752 | - | −1 | - | - | - | - |
| Genes down-regulated by MVA alone | ||||||||
| Ctsf | cathepsin F | 56464 | −1.1 | - | - | - | - | - |
| Depdc1a | DEP domain containing 1a | 76131 | −1.1 | - | - | - | - | - |
| Diap3 | diaphanous homolog 3 (Drosophila) | 56419 | −1.1 | - | - | - | - | - |
| Hmmr (CD168) | hyaluronan mediated motility receptor (RHAMM) | 15366 | −1 | - | - | - | - | - |
| Tlr11 | toll-like receptor 11 | 239081 | −1 | - | - | - | - | - |
| Genes down-regulated by lsdv and MVA, BUT NOT BY CNPV and FWPV | ||||||||
| Ccl21a | chemokine (C-C motif) ligand 21A (serine) | 18829 | −1.3 | −1.7 | - | - | - | - |
| Ccl21b | chemokine (C-C motif) ligand 21B (leucine) | 100042493 | −1.2 | −1.7 | - | - | - | - |
| Ccl21c | chemokine (C-C motif) ligand 21C (leucine) | 65956 | −1.2 | −1.6 | - | - | - | - |
| Kel | Kell blood group | 23925 | −1.5 | −1.5 | - | - | - | - |
| Slc12a2 | solute carrier family 12, member 2 | 20496 | −1 | −1 | - | - | - | - |
| Timd4 | T cell immunoglobulin and mucin domain containing 4 | 276891 | −1.1 | −1.3 | - | - | - | - |
| Genes down-regulated by CNPV, FWPV AND MVA ONLY, and not LSDV. | ||||||||
| Tspan33 | tetraspanin 33 | 232670 | −1.6 | - | −1.3 | −1.1 | - | - |
| OTHER | ||||||||
| Abca9 | ATP-binding cassette, sub-family A (ABC1), member 9 | 217262 | −1.3 | −1.5 | - | −1.1 | - | - |
| Aplnr | apelin receptor | 23796 | −1.4 | −1.5 | −1.2 | −1.2 | - | - |
| Cd209a | CD209a antigen | 170786 | −1.7 | −2.2 | −1.1 | −1.5 | - | - |
| Cd209b | CD209b antigen | 69165 | −1.2 | −1.3 | - | - | - | - |
| Cldn13 | claudin 13 | 57255 | −1.5 | −1.2 | −1.1 | - | - | - |
| Emr4 | EGF-like module containing, mucin-like, hormone receptor-like sequence 4 | 52614 | −1.4 | −1.8 | −1.1 | −1.5 | −1.3 | - |
| Fcamr | Fc receptor, IgA, IgM, high affinity | 64435 | −1.1 | - | −1.5 | - | - | - |
| Fcer2a | Fc receptor, IgE, low affinity II, alpha polypeptide | 14128 | −2.6 | −3 | −2.4 | −2.5 | −2.2 | −1.3 |
| H2-M2 | histocompatibility 2, M region locus 2 | 14990 | −1 | −1.4 | −1 | −1 | −1.1 | - |
| Hs3st2 | heparan sulfate (glucosamine) 3-O-sulfotransferase 2 | 195646 | −1.4 | −1.3 | −1 | −1 | - | - |
| Ifi27l1 | interferon, alpha-inducible protein 27 like 1 | 52668 | −1.4 | −1.3 | - | - | - | - |
| Mgst3 | microsomal glutathione S-transferase 3 | 66447 | −1.6 | −1 | - | −1 | - | - |
| Slc16a10 | solute carrier family 16 (monocarboxylic acid transporters), member 10 | 72472 | −1.4 | - | - | −1.1 | - | - |
| Slc2a4 | solute carrier family 2 (facilitated glucose transporter), member 4 | 20528 | −1.7 | −1 | - | −1.1 | - | - |
| Slc38a5 | solute carrier family 38, member 5 | 209837 | −1.4 | −1.2 | −1 | - | - | - |
| Slc6a20a | solute carrier family 6 (neurotransmitter transporter), member 20A | 102680 | −1.4 | −1.3 | −1 | −1 | - | - |
| Tfrc | transferrin receptor | 22042 | −1.2 | - | - | - | - | - |
| Tspan8 | tetraspanin 8 | 216350 | −1.4 | - | - | −1 | - | - |
Italics genes down-regulated by LSDV alone
Bold Genes down-regulated by MVA alone
Underlined genes down-regulated by LSDV and MVA, but not by avipoxviruses
Italics and underlined genes down-regulated by CNPV, FWPV and MVA only, and not LSDV