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. Author manuscript; available in PMC: 2016 Feb 26.
Published in final edited form as: Cell. 2015 Feb 26;160(5):928–939. doi: 10.1016/j.cell.2015.02.002

Figure 4. TEL1 Deletion Exacerbates ETI Cell Cycle and Lifespan Phenotypes but not Senescence or Telomere Shortening Rates.

Figure 4

Mother cell budding profiles for tel1Δ (A) and tlc1Δ tel1Δ (B). (C) tel1Δ (n=38) strain lifespan does not differ from WT. (D) tlc1Δ tel1Δ (n=83) mutation worsens the lifespan reduction caused by ETI mutations in mother cells (p-value < 1e-4, compared with tlc1Δ alone). (E) ETI and ETI tel1Δ mutants displayed similar rates of senescence when passaged on solid media. (F) Southern blot analysis of telomeric DNA restriction fragment lengths of cells taken from plates after serial streaks shown in (E).

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