Fig. 1.

Slight species differences in Aβ sequence lead to marked differences in Aβ aggregation properties. Note positions 5, 10, and 13 of the Aβ sequence, where species differences between human and mouse Aβ are evident. Only position 13 differs between human and NMR (histidine and arginine, respectively) (A). Nevertheless, NMR and mouse/rat Aβ have a lower propensity to aggregate than the human form (ANOVA, p = 0.011), as measured by the change in kinetic florescence of ThT (B). Data are presented as mean ± SEM for triplicates of each sample.