Table 1C.

Monoaminergic drugs – Clonidine + Cyproheptadine

Authors Year Country Score Research Design Sample Size	Methods	Outcomes	Side Effects
Fung et al. 1990 Canada Downs & Black = 11 Post-test N = 2 Combined with locomotor training	Population: 2 males; age 26 and 23 yrs; T4-7 and C7-8 lesion level; 11 and 8 months post-injury. Treatment: Cyproheptadine 24 mg/day and Clonidine 0.175 mg/0.20 mg/day. Subjects were also taking baclofen. After medications were stabilized for 2 weeks, subjects participated in locomotor training. Outcome measures: Surface EMG and kinematic gait analysis during treadmill walking. No statistical analysis.	Subjects that were originally wheelchair-users could walk overground with assistive devices while on medication. EMG activity became more phasic with less clonus. Subjects showed further improvement in gait patterns and over ground walking after the addition of locomotor training.	Cyproheptadine was administered first and the side effects associated with this drug included increased appetite and drowsiness. When Clonidine was added, subjects experienced dryness of eyes and mouth, lethargy and dizziness.
Norman et al. 1998 Canada Downs & Black = 13 Pre-post N=12	See Table 1A