. 2008 Apr 15;13(6):1043–1058. doi: 10.1111/j.1582-4934.2008.00347.x

Table 2.

The potential strategies to improve humanized mouse model

	Strategies	Targets/purposes	Refs
Recipient mouse selection	NOD/SCID/γc^null mice or Rag2^nulγc^null mice	Deficient in T, B and NK cells	[5, 10]
	Anti-CD122, anti-asialo GM-1 or TM-β1 antibody	Depletion of NK cells	[12, 35, 36, 50–52]
	Liposome-encapsulated dichloromethylene-bisphosphonate	Depletion of macrophages	[11]
Pre-treatments of recipient mice	Specific antibody	Depletion of neutrophils	[106, 125]
	Specific antibody	Depletion of granulocytes	[107, 176]
	Irradiation	Making space	[66]
	TNFα, IL-15, IL-18, rhGH, rhPRL	Growth/Stimulating factors	[56, 58, 62, 64, 65, 177]
Transplantation strategies	Co-transplantation of human foetal thymus/liver tissues and CD34⁺ HSCs	Enhance the resource for human HSCs and immune cells	[13]