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Aβ1–40 and Aβ1–42 are taken up by mitochondria through the TOM machinery. After import most of the Aβ will reside in the inner mitochondrial membrane, where it possibly can inhibit the respiration chain (CI-V) resulting in an increased production of ROS. However, a fraction will also reach the matrix where it either can be degraded by proteases like PreP and IDE or interact with proteins such as CypD and ABAD.
