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Intracrine metabolism of the dehydroepiandrosterone sulphate (DHEA-S) pro-hormone to various sex steroids. DHEA-sulphate can be subjected to desulphation by steroid sulphatase, but the desulphated DHEA can again be resulphated by sulfotransferase. DHEA is further metabolized by the following key enzymes as shown in the figure: 3β-hydroxysteroid dehydrogenase/Δ5-Δ4-isomerase (3β-HSD), 17β-HSD, 5α-reductase and/or aromatase.
