Figure 1.

Allogeneic immune response against necrotic cells in WT and Anx A5 KO mice. WT and KO mice were immunized three times i.p. with allo-geneic primary or secondary necrotic Sp2O cells, respectively. The specific cellular immune response was monitored with the delayed type hypersensivity reaction (DTH test) and is indicated as percentage footpad swelling of the mice. Note: WT mice showed a strongly enhanced immune response in comparison to Anx A5 KO animals. This response was also significantly higher against fresh primary necrotic cells in comparison to secondary necrotic cells. Three independent experiments with always four mice per group were performed. KO: knock out; WT: wild type; *P < 0.05; **P < 0.01