Figure 6. Identification of transcription factor motifs found in cyclin D1^WT and cyclin D1^KE interval sequences.

(A) Selection of transcription factor motif hits common between Cyclin D1^WT and cyclin D1^KE interval sequences (B) Representative TF motifs found in the interval regions associated with cyclin D1^WT and cyclin D1^KE (C) Luciferase reporter gene assays were conducted using the Peroxisome Proliferator-Activated Receptor γ (AOX-LUC) (left panel) and Hypoxia Responsive Element (HRE-LUC) (right panel) luciferase reporter constructs. The number of responsive elements for each construct is depicted in the reporter schematic. HEK293T cells were co-transfected with cyclin D1 (50 ng). Data are of n = 2 separate experiments, mean ± SEM.