Figure 2. Tumor growth in PDXs treated with vehicle or p38 MAPK inhibitor.

Mice with xenografted tumors of about 150-200 mm³ were treated orally with the p38 MAPK inhibitor PH797804 or vehicle and tumor growth was monitored. CCR-10 and CCR-024 were treated for 10 days and CCR-038 for 16 days. Tumor sizes were measured at the indicated time points and normalized to the original size of each tumor when the treatment began. Graphs show the relative tumor growth in vehicle or PH797804-treated PDXs. Data represent means ± SEM (n ≥ 4). ^*, p < 0.05.